胡文萍

姓名：胡文萍

职称：副研究员

专业：生物化学与分子生物学

研究方向：新型基因编辑工具研发、动物基因编辑和遗传育种

招生专业方向：动物遗传育种与繁殖、畜牧、生物化学与分子生物学

联系电话：15901106848

E-mail： huwenping@caas.cn

个人信息

     胡文萍，1985年2月生，博士，副研究员，硕士生导师。2006年获得南昌大学生物工程专业学士学位和工商管理专业第二学士学位；2012年-2013年在美国伊利诺伊大学厄巴纳香槟分校博士联合培养；2014年获得中国农业大学生物化学与分子生物学专业博士学位。2014年7月至今在中国农业科学院北京畜牧兽医研究所工作，现任畜禽种质资源保护与利用创新团队骨干专家。

 研究方向和成果

主要从事新型基因编辑工具研发，动物基因编辑和遗传育种研究。主持国家自然科学基金生物育种青年专项1项、国家自然科学基金青年项目1项、国家重大项目（保密项目）1项和中央级公益性科研院所专项资金项目2项，参加国家自然科学基金国际合作项目和院企合作研发项目等共10余项。共发表学术论文136篇，其中SCI论文51篇（IF：154.9），核心期刊论文85篇。在《Journal of Animal Science and Biotechnology》 《Cells》《Journal of Proteomics》《Proteomics》《BMC Genomics》等杂志以第一作者或通讯作者发表SCI论文23篇（IF：76.1）；在《畜牧兽医学报》 《中国农业大学学报》等核心期刊以第一作者或通讯作者发表论文8篇。担任《Frontiers in Veterinary Science》杂志编辑，《Journal of Celluar physiology》《Frontiers in Nurtrion》和《农业生物技术学报》等杂志审稿专家。授权国家发明专利16项，实用新型专利1项，软件著作权2项。参与培育了“鲁西黑头羊”和“鲁中肉羊”新品种两个，其中鲁中肉羊推广到全国20个省、自治区，入选2022中国农业农村重大科技新成果，2023年畜禽主导品种。参与制定行业标准和团体标准等共9项。参编专著3部。担任科普公众号主编，获农业农村部办公厅2024年度科普成绩突出个人，并通报表扬。在国际学术会议做特邀学术报告，并在国内外重要学术会议中获得多次奖励和荣誉。

  科研项目

1．国家自然科学基金生物育种青年专项，畜禽新型超小型迷你基因编辑器TnpB研制，项目负责人

2．畜禽生物育种全国重点实验室青年英才项目，动物新型高效基因编辑器 Cas12 研制，项目负责人

3．国家重大项目（保密项目），项目负责人

4．国家自然科学基金青年基金项目，绵羊Izumo1和Juno基因之间的功能互作和表达差异，项目负责人

5．中央级公益性科研院所基本科研业务费专项，滩羊多羔BMPRIB基因编辑技术研究，项目负责人

6．中央级公益性科研院所基本科研业务费专项，Juno和pappa2基因与绵羊产羔数性状的相关性研究，项目负责人

7．国家自然科学基金国际（地区）合作与交流项目，非洲和中东绵羊多羔性状的特异分子遗传学机制研究，项目骨干

代表性论文

1． Wenping Hu, Xinlong Dong, Zhilong Tian, Zhuangbiao Zhang, Jishun Tang, Benmeng Liang, Qiuyue Liu* and Mingxing Chu*. Expression, structure and function analysis of the sperm-oocyte fusion genes Juno and Izumo1 in sheep (Ovis aries). Journal of Animal Science and Biotechnology, 2021,12(1):37（中科院一区Top杂志，卓越期刊领军期刊）

2．Wenping Hu^#, Xinyue Wang^#, Yazhen Bi, Jingjing Bao, Mingyu Shang, Li Zhang^*. The Molecular Mechanism of the TEAD1 Gene and miR-410-5p Affect Embryonic Skeletal Muscle Development: A miRNA-Mediated ceRNA Network Analysis. Cells 2023,12,943.

3．Jianqi Yang, Jishun Tang, Xiaoyun He, Ran Di, Xiaosheng Zhang, Jinlong Zhang, Xiaofei Guo, Wenping Hu*, Mingxing Chu*. Key mRNAs and IncRNAs of Pituitary that Affect the Reproduction of FecB++ Small Tail Han Sheep. BMC genomics,2024,25:392

4． Yongfu La, Jishun Tang, Xiaofei Guo, Liping Zhang, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Wenping Hu*, Mingxing Chu*. Proteomics analysis of sheep uterus reveals its role in prolificacy. Journal of Proteomics, 2020, 210：103526（中科院一区Top杂志，院选SCI核心期刊）

5． Jishun Tang^#, Wenping Hu^#, Sheng Chen, Ran Di, Qiuyue Liu, Xiangyu Wang, Xiaoyun He, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Wei Chen , Mingxing Chu*.The Genetic Mechanism of High Prolificacy in Small Tail Han Sheep by Comparative Proteomics of Ovaries in the Follicular and Luteal Stages. Journal of Proteomics, 2019, 204: 103394（中科院一区Top杂志，院选SCI核心期刊）

6． Zhuangbiao Zhang^#, Jishun Tang^#, Ran Di, Qiuyue Liu, Xiangyu Wang, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Wei Chen, Wenping Hu*, Mingxing Chu*. Identification of Prolificacy-related Differentially Expressed Proteins from Sheep (Ovis aries) Hypothalamus by Comparative Proteomics. Proteomics, 2019, 19(14): e1900118（院选SCI核心期刊）

7． Wenping Hu^#, Haixue Zheng^#, Qiuyan Li, Yuhang Wang, Xiangtao Liu, Xiaoxiang Hu , Wenjie Liu, Shen Liu, Zhisheng Chen, Wenhai Feng , Xuepeng Cai*, Ning Li*. shRNA Transgenic Swine Display Resistance to Infection with the Foot-and-Mouth Disease Virus. Scientific Reports. 2021,11(1):16377

8． Zhuangbiao Zhang^#, Jishun Tang^#, Ran Di, Qiuyue Liu, Xiangyu Wang, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Mingxing Chu*, Wenping Hu*. Integrated Hypothalamic Transcriptome Profiling Reveals the Reproductive Roles of mRNAs and miRNAs in Sheep. Frontiers in Genetics, 2020, 10:1296

9． Yongfu La, Xiaoyun He, Liping Zhang, Ran Di, Xiangyu Wang, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Wenping Hu*, Mingxing Chu*.Comprehensive analysis of differentially expressed profiles of mRNA, lncRNA and circRNA in the uterus of seasonal reproduction sheep. Genes, 2020, 11（3）：301

10． Yongfu La^#, Jishun Tang^#, Xiaoyun He, Ran Di, Xiangyu Wang, Qiuyue Liu, Liping Zhang, Xiaosheng Zhang, Jinlong Zhang, Wenping Hu*, Mingxing Chu*. Identification and characterization of mRNAs and lncRNAs in the uterus of polytocous and monotocous Small Tail Han sheep (Ovis aries). PeerJ, 2019, 7:e6938

代表性专利、新品种等

1．“鲁中肉羊”新品种，（农03）新品种证字第20号，推广到全国20个省、自治区，入选2022中国农业农村重大科技新成果，2023年畜禽主导品种。

2．发明专利：与绵羊多羔相关的SNP分子标记及其应用，ZL201810847316.2，第一发明人

3．发明专利：一种高效率的绵羊胚胎骨骼肌原代细胞培养方法，ZL202110740406.3，第二发明人

4．发明专利：一种绵羊胚胎来源成肌细胞的传代纯化方法，ZL 202210506931.3，第二发明人

5．发明专利：与绵羊产羔数性状相关的 SNP分子标记及应用，ZL201810847318.1，第二发明人

6．软件著作权：利用原核注射方法制备基因编辑绵羊试验记录系统V1.0，2019SR1274701，第一著作权人

7．软件著作权：基因编辑绵羊营养调控系统V1.0，2019SR1274701，第二著作权人

8．标准：《肉羊生产性能测定技术规范》团体标准，T CAAA 080-2022，第二起草人

9．标准：《特克赛尔种羊》团体标准，T CAAA 081-2022，第二起草人

10．标准：《羊人工授精操作规程》团体标准，T CAAA 082-2022，第二起草人

  （简历更新时间：2025年2月25日）

 

 

 

 

 

 

 

 

 

Name: Wenping Hu

Title: Associate Professor

Major: Biochemistry and Molecular Biology

Research direction: Development of new gene editing tools, animal gene editing, and genetic breeding

Enrollment majors: Animal Genetics, Breeding and Reproduction, Livestock, Biochemistry and Molecular Biology

Contact number: 15901106848

Email: huwenping@caas.cn

 

Personal Information

Wenping Hu , born in February 1985, Ph. D, associate professor, and a master's supervisor. In 2006, she obtained a bachelor's degree in bioengineering and a second bachelor's degree in business administration from Nanchang University; From 2012 to 2013, jointly trained as a doctoral candidate at the University of Illinois at Urbana Champaign in the United States; In 2014, she obtained Ph. D in biochemistry and molecular biology from China Agricultural University. From July 2014 to now, she has worked in Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, currently serving as a key expert in Animal Genetic Resources group.

 

Research direction and achievements

She mainly engaged in research on development of new gene editing tools, animal gene editing, and genetic breeding research, hosted one National Natural Science Foundation of China Youth Special Project for Biological Breeding, one National Natural Science Foundation Youth Project, one National Major Projects (Confidential Projects) and two Central level Public Welfare Research Institute Special Fund Projects, Participated in more than ten National Natural Science Foundation International Cooperation Projects and Institute Enterprise Cooperation Research and Development Projects. She published 136 academic papers, including 51 SCI papers (IF: 154.9) and 85 core journal papers. She published 23 SCI papers (IF: 76.1) as first author or corresponding author in journals such as Journal of Animal Science and Biotechnology, Cells, Journal of Proteomics, Proteomics and BMC Genomics; published 8 papers as the first author or corresponding author in core journals. She Served as the associate editor of Frontiers in Veterinary Science, as well as an expert reviewer for journals such as Journal of Cellular Physiology, Frontiers in Nutrition, and Journal of Agricultural Biotechnology. She Authorized 16 national invention patents, one utility model patent, and two software copyrights. She Participated in the cultivation of two new breeds of "Luxi Blackhead Sheep" and "Luzhong Meat Sheep". "Luzhong Meat Sheep" promoted to 20 provinces and autonomous regions across the country, selected as a major scientific and technological new achievement in China's agriculture and rural areas in 2022, and a leading livestock and poultry variety in 2023. She participated in the development of nine industry, and group standards. Participated in the compilation of three monographs. Served as the editor in chief of science popularization official account, and won outstanding achievements in science popularization in 2024 from the General Office of the Ministry of Agriculture and Rural Affairs, and was commended in a circular. She made a plenary lecture at an international academic conference and received multiple awards and honors at important academic conferences both domestically and internationally.

 

Scientific research projects

1.        National Natural Science Foundation of China Youth Special Project for Biological Breeding, Development of a new subminiature gene editor TnpB for livestock and poultry, Project Leader

1.        National Key Laboratory of Livestock and Poultry Breeding Young Talents Project, Development of, a New and Efficient Gene Editor Cas12 for Animals, Project Leader

2.        National major projects (confidential projects), project leader

3.        National natural science foundation youth fund project, Functional interaction and expression differences between Izumo1 and Juno genes in sheep, Project Leader

4.        Special fund for basic scientific research of central level public welfare research institutes, Research on BMPRIB gene editing technology for Tan sheep, Project leader

5.        Special fund for basic scientific research of central level public welfare research institutes, Research on the correlation between Juno and pappa2 genes and sheep litter size traits, Project leader

6.        International (regional) cooperation and exchange project of the national natural science foundation of China, Research on specific molecular genetics mechanism of lambing traits in sheep in Africa and the Middle East, Main executor

 

Representative Papers

1．Wenping Hu, Xinlong Dong, Zhilong Tian, Zhuangbiao Zhang, Jishun Tang1, Benmeng Liang, Qiuyue Liu^* and Mingxing Chu^*. Expression, structure and function analysis of the sperm-oocyte fusion genes Juno and Izumo1 in sheep (Ovis aries). Journal of Animal Science and Biotechnology, 2021,12(1):37

2．Wenping Hu^#, Xinyue Wang^#, Yazhen Bi, Jingjing Bao, Mingyu Shang, Li Zhang^*. The Molecular Mechanism of the TEAD1 Gene and miR-410-5p Affect Embryonic Skeletal Muscle Development: A miRNA-Mediated ceRNA Network Analysis. Cells, 2023,12,943.

3．Jianqi Yang, Jishun Tang, Xiaoyun He, Ran Di, Xiaosheng Zhang, Jinlong Zhang, Xiaofei Guo, Wenping Hu*, Mingxing Chu*. Key mRNAs and IncRNAs of Pituitary that Affect the Reproduction of FecB++ Small Tail Han Sheep. BMC genomics,2024,25:392

4． Yongfu La, Jishun Tang, Xiaofei Guo, Liping Zhang, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Wenping Hu*, Mingxing Chu*. Proteomics analysis of sheep uterus reveals its role in prolificacy. Journal of Proteomics, 2020, 210：103526

5． Jishun Tang^#, Wenping Hu^#, Sheng Chen, Ran Di, Qiuyue Liu, Xiangyu Wang, Xiaoyun He, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Wei Chen , Mingxing Chu*.The Genetic Mechanism of High Prolificacy in Small Tail Han Sheep by Comparative Proteomics of Ovaries in the Follicular and Luteal Stages. Journal of Proteomics, 2019, 204: 103394

6． Zhuangbiao Zhang^#, Jishun Tang^#, Ran Di, Qiuyue Liu, Xiangyu Wang, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Wei Chen, Wenping Hu*, Mingxing Chu*. Identification of Prolificacy-related Differentially Expressed Proteins from Sheep (Ovis aries) Hypothalamus by Comparative Proteomics. Proteomics, 2019, 19(14): e1900118

7． Wenping Hu^#, Haixue Zheng^#, Qiuyan Li, Yuhang Wang, Xiangtao Liu, Xiaoxiang Hu , Wenjie Liu, Shen Liu, Zhisheng Chen, Wenhai Feng , Xuepeng Cai*, Ning Li*. shRNA Transgenic Swine Display Resistance to Infection with the Foot-and-Mouth Disease Virus. Scientific Reports. 2021,11(1):16377

8． Zhuangbiao Zhang^#, Jishun Tang^#, Ran Di, Qiuyue Liu, Xiangyu Wang, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Mingxing Chu*, Wenping Hu*. Integrated Hypothalamic Transcriptome Profiling Reveals the Reproductive Roles of mRNAs and miRNAs in Sheep. Frontiers in Genetics, 2020, 10:1296

9． Yongfu La, Xiaoyun He, Liping Zhang, Ran Di, Xiangyu Wang, Shangquan Gan, Xiaosheng Zhang, Jinlong Zhang, Wenping Hu*, Mingxing Chu*.Comprehensive analysis of differentially expressed profiles of mRNA, lncRNA and circRNA in the uterus of seasonal reproduction sheep. Genes, 2020, 11（3）：301

10． Yongfu La^#, Jishun Tang^#, Xiaoyun He, Ran Di, Xiangyu Wang, Qiuyue Liu, Liping Zhang, Xiaosheng Zhang, Jinlong Zhang, Wenping Hu*, Mingxing Chu*. Identification and characterization of mRNAs and lncRNAs in the uterus of polytocous and monotocous Small Tail Han sheep (Ovis aries). PeerJ, 2019, 7:e6938

 

Representative patents, new varieties, etc

1．The new variety of "Luzhong Meat Sheep", New Variety Certificate No. 20, Promoted to 20 provinces and autonomous regions across the country, selected as a major scientific and technological new achievement in China's agriculture and rural areas in 2022, and a leading livestock and poultry variety in 2023

2．Invention patent: SNP molecular markers related to sheep lambs and their applications, ZL201810847316.2, First inventor

3．Invention patent: An efficient method for primary cell culture of sheep embryonic skeletal muscle, ZL202110740406.3, Second inventor

4．Invention patent: A method of passage and purification of sheep embryo derived Muscle cell, ZL 202210506931.3, Second inventor

5．Invention Patent: SNP molecular markers and applications related to litter size traits in sheep, ZL201810847318.1, Second inventor

6．Software Copyright: Record system of preparing gene editing sheep using prokaryotic injection method , V1.02019SR1274701 , First inventor

7．Software Copyright: Gene editing sheep nutrition regulation system V1.02019SR1274701, Second inventor

8．Standard: "Technical Specification for Performance Determination of Meat Sheep Production", T CAAA 080-2022, Second drafter

9．Standard: "Texel Sheep"， T CAAA 081-2022, Second Drafter

10． Standard: "Operation Regulations for Sheep Artificial insemination", T CAAA 082-2022, Second drafter

(Resume update date: Feb 25, 2025)